Patients with versus without diabetes, without CAD, were more often treated with statins and aspirin
TUESDAY, June 20, 2017 (HealthDay News) -- For patients undergoing coronary angiography (CAG), those with and without diabetes without coronary artery disease (CAD) have the same risk of death, cardiac death, and myocardial infarction, according to a study published online June 8 in Diabetes Care.
 
Kevin K.W. Olesen, M.D., from the Aarhus University Hospital in Denmark, and colleagues stratified a population-based cohort of patients registered in the Western Denmark Heart Registry who underwent CAG according to the presence or absence of obstructive CAD and diabetes. Data were included for 93,866 patients, of whom 13.4 percent had diabetes at the time of CAG.
 
During a median follow-up of 4.1 years, the researchers found that the adjusted risk of death (rate ratio, 1.03; 95 percent confidence interval, 0.92 to 1.15), cardiac death (rate ratio, 1.21; 95 percent confidence interval, 0.90 to 1.64), and myocardial infarction (rate ratio, 0.88; 95 percent confidence interval, 0.65 to 1.17) was the same for patients with and without diabetes without obstructive CAD. Compared to patients without diabetes and CAD, patients with diabetes without CAD were more often treated with statins (75.3 versus 46.0 percent) and aspirin (65.7 versus 52.7 percent).
 
"In a real-world population, patients with diabetes with high rates of statin and aspirin treatment had the same risk of cardiovascular events as patients without diabetes in the absence of angiographically significant CAD," the authors write.
 
 
Nyhetsinfo
 
Patients With and Without Diabetes Without Significant Angiographic Coronary Artery Disease Have the Same Risk of Myocardial Infarction in a Real-World Population Receiving Appropriate Prophylactic Treatment
Kevin K.W. Olesen, Morten Madsen, Gro Egholm, Troels Thim, Lisette O. Jensen, Bent Raungaard, Hans E. Bøtker, Henrik T. Sørensen and Michael Maeng
 
Diabetes Care 2017 Jun; dc162388. https://doi.org/10.2337/dc16-2388
 
Abstract
OBJECTIVE The risk of myocardial infarction (MI) in patients with diabetes is greater than for patients without diabetes. Consequently, prophylactic treatment is recommended for patients with diabetes and risk factors for ischemic heart disease.
 
We aimed to estimate the risk of adverse cardiac events in patients with and without diabetes with and without coronary artery disease (CAD) after coronary angiography (CAG).
 
RESEARCH DESIGN AND METHODS A population-based cohort of patients registered in the Western Denmark Heart Registry who underwent CAG between 1 January 2003 and 31 December 2012 was stratified according to the presence or absence of obstructive CAD and diabetes. End points were death, cardiac death, and MI. Unadjusted and adjusted rate ratios (RRs) were calculated by using patients without diabetes and without CAD as the reference group.
 
RESULTS We included 93,866 patients of whom 12,544 (13.4%) had diabetes at the time of CAG. Median follow-up was 4.1 years. Patients with and without diabetes without obstructive CAD had the same adjusted risk of death (RR 1.03 [95% CI 0.92–1.15]), cardiac death (RR 1.21 [95% CI 0.90–1.64]), and MI (RR 0.88 [95% CI 0.65–1.17]). Patients with diabetes without CAD were more often treated with statins (75.3% vs. 46.0%) and aspirin (65.7% vs. 52.7%) than patients without diabetes and CAD.
 
CONCLUSIONS In a real-world population, patients with diabetes with high rates of statin and aspirin treatment had the same risk of cardiovascular events as patients without diabetes in the absence of angiographically significant CAD.
 
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